08 Corcoran 01-01.qxd
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چکیده
January 2001 3 This review explores the neurobiology of stress and its possible role in the etiology of schizophrenia. Major life events may play a role in onset and relapse in schizophrenia. Other data suggest that early stress exposure increases schizophrenia risk, especially in individuals with latent vulnerability. Animal research has led to an elucidation of the mechanisms by which stress and cortisol are toxic to the hippocampus and impair cognition. Associations among these factors have been found in a variety of human conditions, including psychiatric illness and normal aging. These mechanisms are plausible in schizophrenia, which is characterized by a degree of cortisol dysregulation, hippocampal abnormality, and cognitive impairment. Characterization of the role of the stress cascade in schizophrenia has implications for novel pharmacologic and other treatment, especially for cognitive symptoms, which are debilitating and largely refractory to treatment. (Journal of Psychiatric Practice 2001;7:3–14)
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Bjp-2011-101816 1..8
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متن کامل• Beer mats and backs of envelopes • Notebooks
1967 Berkeley 1968 Berkeley 1969 Asilomar 1970 Tucson 1971 Asilomar 1972 Claremont 72:01–72:05 1973 Los Angeles 73:01–73:16 1974 Los Angeles 74:01–74:08 1975 Asilomar 75:01–75:23 1976 San Diego 1–65 i.e., 76:01–76:65 1977 Los Angeles 101–148 i.e., 77:01–77:48 1978 Santa Barbara 151–187 i.e., 78:01–78:37 1979 Asilomar 201–231 i.e., 79:01–79:31 1980 Tucson 251–268 i.e., 80:01–80:18 1981 Santa Bar...
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متن کاملTotal blood lymphocyte counts in hemochromatosis probands with HFE C282Y homozygosity: relationship to severity of iron overload and HLA-A and -B alleles and haplotypes
BACKGROUND It has been reported that some persons with hemochromatosis have low total blood lymphocyte counts, but the reason for this is unknown. METHODS We measured total blood lymphocyte counts using an automated blood cell counter in 146 hemochromatosis probands (88 men, 58 women) with HFE C282Y homozygosity who were diagnosed in medical care. Univariate and multivariate analyses of total...
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تاریخ انتشار 2001